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Stories from the history of drug safety. News from the regulatory frontlines. Trends shaping the future of pharmacovigilance.

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News16 March 2026

Weekly Safety Briefing: March 10–16, 2026

EMA PRAC recommends new contraindication for a biologic, FDA issues safety communication on GLP-1 receptor agonists, and WHO publishes updated guidance on vaccine pharmacovigilance in low-resource settings.

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Story15 March 2026

The Signal That Changed Everything: How Rofecoxib Reshaped Drug Safety

The withdrawal of Vioxx in 2004 didn't just remove a drug from the market — it fundamentally transformed how the pharmaceutical industry thinks about cardiovascular safety signals and long-term post-marketing surveillance.

Trend1 March 2026

The Quiet Revolution: How AI Is Reshaping Signal Detection

Traditional disproportionality analysis has been the backbone of quantitative signal detection for decades. A new generation of AI-powered approaches is beginning to supplement — and in some cases challenge — this established paradigm.

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