Trends

Where pharmacovigilance is heading. Analysis of the emerging science, regulatory shifts, and technology shaping the next decade of drug safety.

Trend·March 1, 2026·4 min read

The Quiet Revolution: How AI Is Reshaping Signal Detection

Traditional disproportionality methods — PRR, BCPNN, MGPS — have been the backbone of safety signal detection for two decades. A new generation of AI-augmented approaches is not replacing them but fundamentally changing what 'signal detection' means.